Hi there! My name is Serena Giannelli and I’m a PhD student from Università degli Studi di Torino.

During these years I investigated the pathogenetic mechanisms due to the Alzheimer’s disease, the most common form of dementia, in the lab led by Professor Gabriella Leonarduzzi (Department of Clinical and Biological Sciences, University of Turin). I am currently spending a semester abroad at Karolinska Institutet thanks to the great support of C.M. Lerici Foundation.

Dementia affects more than 50 million people worldwide, with a new case occurring somewhere in the world every 3 seconds but, unfortunately, no effective cure is available so far. For this reason, the identification of attractive targets for novel therapeutic interventions represents one of the major challenges for our future.

My research focuses on the beneficial effect of 24-hydroxycholesterol, the major brain cholesterol metabolite. Maintaining its levels high in the brain might be useful to fight neurodegeneration and to slow down the progression of Alzheimer’s disease.

I would like to thank Professor Silvia Maioli (NVS, Division of Neurogeriatrics, BlioClinicum, Karolinska Institutet) for hosting me in her laboratory and giving me the opportunity to improve my skills in the amazing world of the Neuroscience.

At the same time, I’m discovering all the gems Stockholm has to offer: from the colourful sunsets to the characteristic cinnamon smell of its “Kanelbullar”, one of the traditional dishes you can taste during the Swedish FIKA.

C. M. Lerici Foundation, thank you so much.

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